Key result
Approximate entropy (P<0.001) and scaling exponent alpha(1) (P<0.05) progressively decreased before spontaneous onset of paroxysmal atrial fibrillation in patients without structural heart disease.
Why the study?
Do nonlinear heart rate variability measures (ApEn and alpha(1)) change before the spontaneous onset of paroxysmal AF in patients without structural heart disease compared to healthy controls?
Observational (n=22)
Do nonlinear heart rate variability measures (ApEn and alpha(1)) change before the spontaneous onset of paroxysmal AF in patients without structural heart disease compared to healthy controls?
p-value: p=<0.001
A decrease in the complexity and altered fractal properties of R-R intervals precede the spontaneous onset of paroxysmal AF in patients without structural heart disease.
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Nonlinear HRV indices may precede lone paroxysmal AF; leaves open whether they enable monitoring or prevention.
Vikman et al. (1999) conducted an observational in Paroxysmal atrial fibrillation (n=22). Nonlinear heart rate variability analysis vs. Matched healthy control subjects was evaluated on Approximate entropy (ApEn) and short-term scaling exponent alpha(1) before AF onset (p=<0.001). Approximate entropy (P<0.001) and scaling exponent alpha(1) (P<0.05) progressively decreased before spontaneous onset of paroxysmal atrial fibrillation in patients without structural heart disease.
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