Quantitative assessment of endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria
Why the study?
Does quantitative histomorphometric assessment of endomyocardial biopsy provide standardized diagnostic parameters for ARVC/D?
Population
60 explanted hearts from six groups: diffuse ARVC/D, segmental ARVC/D, dilated cardiomyopathy, controls…
Comparison
Simulated in vitro endomyocardial biopsy with a… vs Comparison across different cardiomyopathies…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for quantitative EMB in ARVC/D animal models; leaves open human diagnostic validation.
Structured PICO
Does quantitative histomorphometric assessment of endomyocardial biopsy provide standardized diagnostic parameters for ARVC/D?
P
Population
60 explanted hearts from six groups: diffuse ARVC/D (n=10), segmental ARVC/D (n=10), dilated cardiomyopathy (n=10), controls (n=10), adipositas cordis (n=10), and elderly >80 years (n=10).
I
Intervention
Simulated in vitro endomyocardial biopsy (EMB) with a Cordis bioptome and histomorphometry
C
Comparator
Comparison across different cardiomyopathies, adipositas cordis, elderly, and normal control groups
O
Outcome
Diagnostic cut-offs for the amount of myocardium, fibrous, and fatty tissuessurrogate
In vitro simulation of endomyocardial biopsy demonstrates that residual myocardium <59% is the most sensitive diagnostic morphometric parameter for ARVC/D, while apical fat is non-specific.
Cite This Study
Basso et al. (2008) studied this question.