Why the study?
Is insufficient leaflet remodeling (small total leaflet area/annulus area ratio) associated with the severity of mitral regurgitation in patients with atrial fibrillation?
Is insufficient leaflet remodeling (small total leaflet area/annulus area ratio) associated with the severity of mitral regurgitation in patients with atrial fibrillation?
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In patients with atrial fibrillation, the severity of mitral regurgitation is driven more by insufficient leaflet remodeling relative to annular dilatation than by annular dilatation alone.
BACKGROUND: The relationship between annular dilatation caused by atrial fibrillation (AF) and mitral regurgitation (MR) remains controversial. We hypothesized that the small ratio of total leaflet area/annulus area (TLA/AA), reflecting insufficient leaflet remodeling to annular dilatation, is a main component of MR in patients with AF. METHODS AND CONCLUSIONS: In patients with AF, insufficient leaflet remodeling to annular dilatation, rather than crude annular dilatation, was strongly associated with the severity of MR.
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Kagiyama et al. (2017) studied this question.
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