What question did this study set out to answer?

To synthesize current knowledge on one-carbon metabolism and evaluate how its integrated biochemical pathways influence cellular homeostasis, longevity, and neurodegeneration.

January 9, 2022CellsOpen Access

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

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To synthesize current knowledge on one-carbon metabolism and evaluate how its integrated biochemical pathways influence cellular homeostasis, longevity, and neurodegeneration.
Narrative review synthesizing molecular, nutritional, and cross-species evidence on one-carbon metabolism (OCM).
Analysis of core modules including the folate cycle, methionine cycle, transsulfuration pathway, and their upstream dietary inputs.
One-carbon metabolism coordinates nucleotide synthesis, epigenetic methylation, and glutathione-mediated redox regulation across proliferative and non-proliferative tissues.
Dietary micronutrients directly tune OCM activity, which intersects with metabolic signaling cascades to modulate longevity and neurodegenerative disease phenotypes across species.

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Implication

Literature review demonstrates the critical role of one-carbon metabolism across species, highlighting its impact on cellular homeostasis, longevity, and neurodegenerative disease progression.

Cite This Study

Lionaki et al. (2022) studied this question.

synapsesocial.com/papers/69fbda4c714c9259a2dfa4c8 https://doi.org/10.3390/cells11020214

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Implication

Literature review demonstrates the critical role of one-carbon metabolism across species, highlighting its impact on cellular homeostasis, longevity, and neurodegenerative disease progression.

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

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Discussion

Implication

Cite This Study

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Key Points

Discussion

Implication

Cite This Study

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