Exogenous 8-hydroxydeoxyguanosine prevents liver fibrosis through the regulation of Rac1-NADPH oxidase signaling in a metabolic dysfunction-associated steatohepatitis model

Key Points

• To investigate the effects of 8-hydroxydeoxyguanosine on liver fibrosis in a metabolic dysfunction-associated steatohepatitis model.
• Utilized an animal model replicating human MASH and fibrosis
• Administered 8-hydroxydeoxyguanosine to assess its effects on fibrosis
• Analyzed Rac1-NADPH oxidase signaling pathway related to fibrosis
• 8-hydroxydeoxyguanosine significantly reduced liver fibrosis
• Targeting Rac1-NOX2 signaling pathway was effective
• The animal model provided advantages over traditional models