What question did this study set out to answer?

To evaluate the impact of radiation on normal brain tissue in patients with recurrent glioblastoma using spectroscopic MRI.

May 7, 2026NMR in Biomedicine0 citationsOpen Access

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Radiation Effects on Normal Brain in Subjects With Recurrent Glioblastoma by Spectroscopic MRI

AAAbram AbdouUniversity of Miami SSSulaiman SheriffHenry Ford Health System KRKelly RojasHenry Ford Health System

Key Points

To evaluate the impact of radiation on normal brain tissue in patients with recurrent glioblastoma using spectroscopic MRI.
Examined Cho/NAA ratios before and after radiation therapy
Analyzed dose-response relationships in brain tissue
Used spectroscopic MRI to assess tumor delineation.
Normalized Cho/NAA increased with radiation dose
Mean slope of Cho/NAA increase was 0.0018/Gy (p < 0.001)
Prior radiation modestly elevated baseline Cho/NAA primarily due to NAA reduction.

Abstract

= 0.001, p < 0.001). Accordingly, normalized Cho/NAA increased with dose, with a mean slope of 0.0018/Gy (p < 0.001). A standard Cho/NAA threshold of 2 corresponded to a median of 2.39 (range, 1.91-2.72) in tissue previously receiving 60 Gy. These findings suggest prior RT modestly elevates baseline Cho/NAA, primarily through NAA reduction, and that dose-corrected Cho/NAA maps may improve tumor delineation in recurrent GBM.

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Radiation Effects on Normal Brain in Subjects With Recurrent Glioblastoma by Spectroscopic MRI

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Abstract

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