What question did this study set out to answer?

To assess whether dose escalation to 90 cobalt gray equivalent (CGE) using accelerated fractionated conformal protons and photons improves local tumor control and overall survival in patients with glioblastoma multiforme.

August 1, 1999Journal of neurosurgery

Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial

View Full Paper

Ask AI

Bookmark

To assess whether dose escalation to 90 cobalt gray equivalent (CGE) using accelerated fractionated conformal protons and photons improves local tumor control and overall survival in patients with glioblastoma multiforme.
Enrolled 23 patients aged 18 to 70 years with supratentorial, unilateral glioblastoma multiforme, a Karnofsky Performance Scale score ≥ 70, and residual tumor volume < 60 ml.
Administered accelerated fractionated radiation therapy dose-escalated to 90 CGE combining conformal protons and photons.
Assessed survival outcomes, radiological changes via gadolinium-enhanced MRI, and tissue histology via biopsy, resection, or autopsy in 15 of 23 patients.
Median overall survival was 20 months, with 2-year and 3-year actuarial survival rates of 34% and 18%, representing a 5- to 11-month increase compared to historical controls.
Histology in 15 patients revealed radiation necrosis alone in 7 patients, whose survival was significantly longer than those with recurrent tumor (p = 0.01).
Recurrent tumor occurred primarily in marginal zones receiving ≤ 60 to 70 CGE, with only one recurrence identified within the 90-CGE high-dose volume.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Phase II trial shows dose-escalated proton/photon therapy extends survival in glioblastoma, indicating central tumor control is countered by radiation necrosis.

Cite This Study

Fitzek et al. (1999) studied this question.

synapsesocial.com/papers/6a70d28e6ceb2bbd16e000b7 https://doi.org/10.3171/jns.1999.91.2.0251

View Full Paper

Ask AI

Bookmark

Implication

Phase II trial shows dose-escalated proton/photon therapy extends survival in glioblastoma, indicating central tumor control is countered by radiation necrosis.

Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial

Key Points

Discussion

Implication

Cite This Study

Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider