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May 7, 2026Diabetes Obesity and Metabolism

A Novel Method to Evaluate Insulin Sensitivity by Combining Continuous Glucose Monitoring and Urinary C‐Peptide Excretion

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Authors

GSGuillermo Sánchez‐DelgadoKMKara L. MarlattRBRobbie A. Beyl

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Overview

Combining continuous glucose monitoring and urinary C-peptide improves insulin sensitivity evaluation in adults, suggesting non-invasive alternatives may be viable.

Key Points

  • To assess the efficacy of a new method for evaluating insulin sensitivity using continuous glucose monitoring and urinary C-peptide excretion.
  • Utilized continuous glucose monitoring over 24 hours.
  • Measured 24-hour urinary C-peptide excretion rates.
  • Compared findings with traditional euglycemic-hyperinsulinemic clamp results.
  • 24 h-glycemia/C-peptide ratio is proposed as a promising marker for insulin sensitivity.
  • The method is simple, inexpensive, and non-invasive.
  • Results indicated values ranging from 0.108 to 0.174 for the high-dose clamp.

Cite This Study

Sánchez‐Delgado et al. (2026) studied this question.

synapsesocial.com/papers/69fbe2b3164b5133a91a224fhttps://doi.org/10.1111/dom.70802
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