What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

The aim is to explore the link between premorbid adjustment and long-term outcomes in schizophrenia spectrum disorder.

May 7, 2026European Child & Adolescent PsychiatryOpen Access

Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study

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The aim is to explore the link between premorbid adjustment and long-term outcomes in schizophrenia spectrum disorder.
Data from 496 participants in the OPUS I trial were analyzed.
Premorbid Adjustment Scale assessed retrospective academic and social scores.
Mixed models were used to evaluate effects on social functioning and negative symptoms.
Low social functioning was linked to worse childhood premorbid adjustment.
Severe negative symptoms correlated with impaired social premorbid adjustment in childhood.
Declines in premorbid adjustment during adolescence related to worse outcomes 20 years after SSD onset.

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Implication

Findings show poor premorbid adjustment in childhood affects long-term social functioning in schizophrenia spectrum disorder, indicating need for early support.

Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/69fbe325164b5133a91a25c2 https://doi.org/10.1007/s00787-026-03043-1

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Implication

Findings show poor premorbid adjustment in childhood affects long-term social functioning in schizophrenia spectrum disorder, indicating need for early support.

Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study

Key Points

Discussion

Implication

Cite This Study

Childhood premorbid adjustment as a marker for 20-year impairments in schizophrenia spectrum disorder: results from the OPUS study

Key Points

Discussion

Implication

Cite This Study

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