Investigation reveals transcorneal electrical stimulation improves outcomes in Alzheimer's disease, suggesting potential diagnostic uses of optical coherence tomography imaging.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder lacking reliable noninvasive indicators for early diagnosis. Transcorneal electrical stimulation (TES) has emerged as a noninvasive neuromodulation approach, yet its effects on AD‐related pathology and eye–brain interactions remain unclear. In this study, TES was applied to wild‐type (WT) and AD mice, followed by longitudinal optical coherence tomography (OCT) and OCT angiography (OCTA) imaging of the retina and cerebral cortex over a 30‐day period. Quantitative imaging metrics, together with histologically assessed amyloid‐β (Aβ) plaque deposition, were used to assess TES‐associated structural and neurovascular changes. In addition to retinal thickness, retinal vascular density (VD) was evaluated as an objective, noninvasive imaging metric associated with AD‐related neurovascular alterations. These findings demonstrate the utility of longitudinal OCT/OCTA imaging for investigating intervention‐associated retinal and cerebral neurovascular changes along the eye–brain axis.
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Si et al. (2026) studied this question.
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