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June 19, 2026Open Access

Transcranial pulse stimulation modulates spectral signatures of Alzheimer's disease in the 3×Tg-AD mouse model

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Authors

IGIrmak GezginerMKMaria Eleni KarakatsaniPNPrakruti Nanda

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Overview

Randomized trial reveals modulation of Alzheimer's disease signatures in 3×Tg-AD mice, suggesting new treatment potential.

Key Points

  • This research aims to understand how transcranial pulse stimulation affects brain network dysfunction in Alzheimer's disease models.
  • 3×Tg-AD mice underwent resting-state fMRI to assess functional connectivity following TPS.
  • Novel object recognition testing evaluated short-term memory and exploratory drive after TPS and sham treatment.
  • Acute and longitudinal changes in spectral power and variance were analyzed post-stimulation.
  • AD mice had reduced low-frequency power and connectivity loss; TPS increased low-frequency power and coherence.
  • Effective modulation of spectral features occurred mainly in cingulate, insular, piriform, and striatal regions after repeated stimulation.
  • TPS-treated mice showed preserved exploratory behavior and increased preference for novel objects compared to sham-treated mice.

Cite This Study

Gezginer et al. (2026) studied this question.

synapsesocial.com/papers/6a34de7065a5b0777af2dd87https://doi.org/10.48620/98708
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcranial pulse stimulation modulates spectral signatures of Alzheimer’s disease in the 3×Tg-AD mouse model2026
  2. 2Transcranial pulse stimulation in Alzheimer's disease2023 · 23 citations
  3. 3Electrical brain networks before and after transcranial pulsed shockwave stimulation in Alzheimer’s patients2024 · 10 citations
  4. 4Transcranial Pulse Stimulation in Alzheimer’s: Long-Term Feasibility and a Multifocal Treatment Approach2025
  5. 5Neuronavigated Transcranial Pulse Stimulation (TPS) with shock waves as a novel tool of noninvasive brainstimulation (NIB) for a long-term treatment of Alzheimer’s disease2025