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This research investigates how transcranial pulse stimulation affects brain network activity in an Alzheimer’s disease mouse model.

Transcranial pulse stimulation modulates spectral signatures of Alzheimer’s disease in the 3×Tg-AD mouse model

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Randomized trial shows transcranial pulse stimulation alters brain connectivity in Alzheimer’s model, suggesting new treatment approaches.

This research investigates how transcranial pulse stimulation affects brain network activity in an Alzheimer’s disease mouse model.
3×Tg-AD mice underwent resting-state functional MRI for brain connectivity assessment after treatment with transcranial pulse stimulation or sham treatment.
Both acute and longitudinal effects were evaluated, including functional connectivity, signal power, and variance across frequency bands.
Novel object recognition tests were conducted to assess memory and exploratory behavior following stimulation.
AD mice showed widespread functional connectivity loss with reduced low-frequency power and variance.
TPS increased low-frequency power and improved network coherence, especially in specific brain regions like the cingulate and striatal regions.
Behavioral tests indicated TPS-treated mice maintained exploratory behavior and exhibited increased novelty preference compared to sham-treated mice.

Gezginer et al. (2026) studied this question.

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Randomized trial shows transcranial pulse stimulation alters brain connectivity in Alzheimer’s model, suggesting new treatment approaches.