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May 7, 2026Stroke Vascular and Interventional NeurologyOpen Access

Consensus Guidelines on Inferior Petrosal Sinus Sampling: A Guideline From the Society of Vascular and Interventional Neurology Guidelines and Practice Standards Committee

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Authors

FSFarhan SiddiqUniversity of MissouriHBH. BrooksUniversity of MissouriEDEsra DemirtasUniversity of Missouri

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Implication

Guidelines standardize BIPSS procedures for Cushing disease assessment, highlighting risks and enhancing diagnostic yield.

Key Points

  • The aim is to establish standardized guidelines for inferior petrosal sinus sampling in Cushing disease.
  • A multidisciplinary panel developed recommendations using a systematic review and modified Delphi process.
  • Guideline includes indications for BIPSS, technical approaches, and sampling protocols.
  • Competency benchmarks and quality-assurance metrics are also defined.
  • Standardized BIPSS can provide high sensitivity and specificity for localizing ACTH pathologies.
  • Recommendations address pitfalls like false negatives and sampling errors.

Cite This Study

Siddiq et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3ca164b5133a91a3119https://doi.org/10.1161/svin.125.002309
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Petrosal sinus sampling: technique and rationale.1991 · 152 citations
  2. 2Intercavernous Venous Communications in the Human Skull Base1994 · 39 citations
  3. 3Vasopressin receptor expression and mutation analysis in corticotropin-secreting tumors.1996 · 119 citations
  4. 4Neurologic complications of petrosal sinus sampling.1992 · 163 citations
  5. 5Bilateral inferior petrosal sinus sampling in the diagnosis of ACTH-dependent Cushing’s syndrome: experience in a tertiary hospital2022 · 2 citations