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May 7, 2026Current Pharmaceutical Design

Diosgenin Alleviates Inflammation in the Colon and Hippocampus and PartlyAttenuates Comorbid Autistic-like Behaviors in Experimental Colitis in Mice

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Authors

AAAli AramiShahrekord University of Medical SciencesZLZahra LorigooiniShahrekord University of Medical SciencesHGHourivash GhaderiShahrekord University of Medical Sciences

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Implication

Experimental colitis reduced sociability and increased aggressive behaviors in mice, indicating diosgenin may improve outcomes by alleviating neuroinflammation.

Key Points

  • Assess diosgenin's effects on inflammation and autistic-like behaviors in mice with colitis.
  • Induced colitis in mice using acetic acid and divided them into five treatment groups.
  • Administered diosgenin and saline for seven consecutive days at specified doses.
  • Conducted behavioral tests for sociability, social preference, and memory, followed by dissection of colon and hippocampus.
  • Colitis caused significant behavioral changes, including reduced sociability and increased aggression.
  • Diosgenin treatment mitigated the negative behavioral effects and reduced inflammatory markers in both the colon and hippocampus.

Cite This Study

Arami et al. (2026) studied this question.

synapsesocial.com/papers/69fbe3ca164b5133a91a3127https://doi.org/10.2174/0113816128425033260127191119
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Also Consider

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