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May 7, 2026Diabetes Obesity and Metabolism

Efficacy and Safety of T Cell‐Targeted Immunotherapy in Newly Diagnosed Type 1 Diabetes: A Systematic Review and Meta‐Analysis

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Authors

YWYue WangUniversity of StuttgartYZYuemin ZhouCentral South UniversityMZMinxue ZhuCentral South University

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Overview

Systematic review reveals T cell-targeted immunotherapy improves C-peptide and glycated haemoglobin in type 1 diabetes, suggesting enhanced β-cell preservation and safety.

Key Points

  • To evaluate the efficacy and safety of T cell-targeted immunotherapy in newly diagnosed type 1 diabetes.
  • Conducted a systematic review and meta-analysis of randomised controlled trials
  • Included trials comparing T cell-targeted immunotherapy with placebo
  • Primary outcome was change in C-peptide area under the curve (AUC)
  • T cell-targeted immunotherapy significantly increased C-peptide AUC at various time points
  • Reduced glycated haemoglobin and daily insulin dose
  • Adverse events were comparable between intervention and control groups

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69fbef68164b5133a91a3450https://doi.org/10.1111/dom.70829
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Also Consider

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  2. 2WITHDRAWN2024
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  4. 4Targeting Pathogenic Effector T Cells with a Novel Small-Peptide Approach in Type 1 Diabetes: A First-in-Human, Randomized, Double-Blind, Phase 1b Clinical Trial2026
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