What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

Investigate the role of fibrin degradation products in trauma-induced coagulopathy and their effects on plasmin activity.

May 7, 2026Blood Coagulation & Fibrinolysis

Fibrin degradation products enhance plasmin activity and contribute to fibrinolysis during simulated trauma-induced coagulopathy

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Authors

CHChang Yeop HanResuscitation Council NDNathan Dow NWNathan J. WhiteResuscitation Council

Discussion

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Implication

In vitro analysis shows D-dimer enhances plasmin activity and clot formation in trauma-induced coagulopathy, suggesting a role in excessive fibrinolysis.

Key Points

Investigate the role of fibrin degradation products in trauma-induced coagulopathy and their effects on plasmin activity.
Purified FDPs were tested in normal human plasma under in vitro conditions.
ROTEM assessed clot initiation, formation, firmness, and lysis.
Thrombin generation and plasmin generation assays measured enzymatic activity.
D-dimer significantly increased clot lysis under TIC-like conditions.
D-dimer accelerated plasmin generation, shortening peak time and increasing concentration.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69fbef86164b5133a91a35ff https://doi.org/10.1097/mbc.0000000000001430

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Implication

In vitro analysis shows D-dimer enhances plasmin activity and clot formation in trauma-induced coagulopathy, suggesting a role in excessive fibrinolysis.

Fibrin degradation products enhance plasmin activity and contribute to fibrinolysis during simulated trauma-induced coagulopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Fibrin degradation products enhance plasmin activity and contribute to fibrinolysis during simulated trauma-induced coagulopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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