What type of study is this?

This is a Literature Review study.

What question did this study set out to answer?

This review evaluates payer-manufacturer agreements and pricing strategies for ultra-high-cost therapies in the U.S.

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This review evaluates payer-manufacturer agreements and pricing strategies for ultra-high-cost therapies in the U.S.
Conducted a narrative literature review from 2010 to 2025
Identified peer-reviewed and grey literature through PubMed, Embase, and Google Scholar
Categorized payment models and implementation challenges based on findings
Highlighted diverse pricing approaches across manufacturers
Outcomes-based agreements were common for measurable clinical endpoints
Adoption of payment models varied based on therapy characteristics and payer preferences

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Narrative review examines pricing strategies and agreements for high-cost therapies, revealing issues in implementation.

Persaud et al. (2026) studied this question.

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