“Pregabalin-Loaded Transferosomal Gel for Enhanced Topical Delivery in Peripheral Neuropathy: Formulation, In- Vitro and Ex- Vivo Evaluation”

Mariya Sanjana .A; Ashvini H M

doi:10.1080/03639045.2026.2667232

May 5, 2026Drug Development and Industrial Pharmacy

“Pregabalin-Loaded Transferosomal Gel for Enhanced Topical Delivery in Peripheral Neuropathy: Formulation, In- Vitro and Ex- Vivo Evaluation”

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Key Points

To develop a transferosomal gel for enhanced topical delivery of pregabalin in managing peripheral neuropathy.
Developed a transferosomal gel formulation.
Conducted in-vitro and ex-vivo evaluations of gel performance.
Assessed sustained release and permeation efficiency.
The gel exhibited sustained release properties over time.
Demonstrated effective permeation in ex-vivo tests.
Showed stability for at least 90 days without irritation.

Implication

Formulation of a transferosomal gel shows effective delivery for peripheral neuropathy, suggesting improved treatment options.

Abstract

/h, and a lag time of 0.99 h. The gel was non-irritant and stable for 90 days.ConclusionsThe developed transferosomal gel exhibited sustained release, efficient permeation, and good stability, indicating strong potential as a transdermal system for peripheral neuropathy management.

Discussion

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Cite This Study

.A et al. (2026) studied this question.

synapsesocial.com/papers/69fbefc0164b5133a91a3c6b https://doi.org/10.1080/03639045.2026.2667232

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“Pregabalin-Loaded Transferosomal Gel for Enhanced Topical Delivery in Peripheral Neuropathy: Formulation, In- Vitro and Ex- Vivo Evaluation”

Key Points

Implication

Abstract

Discussion

Cite This Study

“Pregabalin-Loaded Transferosomal Gel for Enhanced Topical Delivery in Peripheral Neuropathy: Formulation, In- Vitro and Ex- Vivo Evaluation”

Key Points

Implication

Abstract

Discussion

Cite This Study

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