Native mass spectrometry uncovers binding modes of p53 in complex with DNA, suggesting the importance of dimer-dimer interactions.
to bind to DNA as tetramers. Binding of a single dimer to an isolated half-site is insufficient for generating the stable tetrameric p53:DNA complex. These findings indicate that dimer-dimer interactions are crucial for stabilizing the tetrameric p53:DNA complex.
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Siefke et al. (2026) studied this question.
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