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May 7, 2026Open Access

Delivery platforms for antiviral and antiinflammatory substances during influenza virus infections

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Authors

JSJosefine SchroederJena University Hospital

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Implication

Investigation found nanocarriers improve bioavailability of antiviral drugs in lung cells, suggesting they enhance treatment efficacy.

Key Points

  • This research aims to explore advanced delivery platforms for antiviral and anti-inflammatory therapies during influenza virus infections.
  • Investigated free and nanocarrier encapsulated compounds in lung epithelial cell lines.
  • Assessed cytotoxicity using LDH assays and MTT assays.
  • Quantified viral replication using plaque assays and Western blot analysis.
  • Measured cytokine responses via flow cytometry.
  • Validated findings with ex vivo mouse lung slices.
  • Both compounds displayed antiviral activity against influenza A viruses.
  • Nanocarrier encapsulation preserved drug efficacy, reducing toxicity for 6 bromoindirubin 3'-glycerol oxime ether.
  • Encapsulated pictilisib showed improved anti-inflammatory effects and performance in ex vivo experiments.

Cite This Study

Josefine Schroeder (2026) studied this question.

synapsesocial.com/papers/69fbefef164b5133a91a403dhttps://doi.org/10.22032/dbt.70251
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