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May 7, 2026Menopause The Journal of The North American Menopause Society

Biological markers of aging across the menopause transition: current evidence

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Authors

RCRegina CastanedaMayo ClinicEUErin R UddenbergUniversity of MiamiMAMaria D. Hurtado AndradeMayo Clinic

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Implication

This review finds that hormonal transitions influence biological aging markers in women during menopause, highlighting potential precision health strategies.

Key Points

  • The review aims to synthesize evidence on aging biomarkers during the menopause transition and their relevance to women's health.
  • Narrative review of human studies and translational research
  • PubMed search to identify relevant literature
  • Focus on aging biomarkers in relation to menopause and hormone therapy
  • Changes in biological aging markers are observed across multiple molecular systems during menopause
  • Postmenopausal status links to elevated markers of biological aging
  • Vasomotor symptoms may correlate with higher epigenetic age
  • Hormone therapy may positively influence certain aging markers

Cite This Study

Castaneda et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a437dhttps://doi.org/10.1097/gme.0000000000002802
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