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May 7, 2026Journal of Liposome Research

Control of breast cancer via anastrozole-loaded transbilosomes

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Authors

MEMarwa H. ElkarmalawyModern University for Information and TechnologyMNMarwa M. NagibMisr International UniversityABAmany BelalTaif University

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Overview

Optimized anastrozole delivery shows improved targeting and safety in breast cancer, suggesting a new therapy approach.

Key Points

  • To assess the efficacy, bioavailability, targeting, and safety of anastrozole-loaded transbilosomes in breast cancer treatment.
  • Used an Ehrlich-induced breast cancer mouse model
  • Compared optimized ALT formulation with free anastrozole
  • Measured tumor volume, mortality rates, and biomarker levels
  • ALT outperformed free anastrozole by 77% in sustainability
  • Bioavailability increased by 7.88 times
  • Tumor volume and mortality rates significantly reduced by 99.08% and 23.33%
  • ALT formulation showed improved safety profile with no adverse effects on kidney or liver functions

Cite This Study

Elkarmalawy et al. (2026) studied this question.

synapsesocial.com/papers/69fbf004164b5133a91a4459https://doi.org/10.1080/08982104.2026.2664882
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