What question did this study set out to answer?

To evaluate the diagnostic efficacy of Ga-FAPI-04 PET/CT versus salivary gland scintigraphy for Sjögren's syndrome.

May 7, 2026EJNMMI ResearchOpen Access

Prospective comparison of 68GaGa-FAPI-04 PET/CT and salivary gland scintigraphy for the diagnosis of primary Sjögren’s syndrome

View Full Paper

Ask AI

Bookmark

Authors

Comparison reveals Ga-FAPI-04 PET/CT improves diagnosis of Sjögren's syndrome, suggesting higher efficacy than salivary gland scintigraphy.

To evaluate the diagnostic efficacy of Ga-FAPI-04 PET/CT versus salivary gland scintigraphy for Sjögren's syndrome.
Conducted a prospective comparison in patients with suspected primary Sjögren’s syndrome.
Analyzed diagnostic results from 21 participants, including 15 with confirmed pSS and 6 controls.
Compared early-phase PET/CT with salivary gland scintigraphy in terms of specificity, accuracy, and sensitivity.
Early-phase PET/CT showed higher specificity (66.7% vs. 16.7%) and overall accuracy (85.7% vs. 71.4%) compared to scintigraphy.
SUVmax of submandibular and sublingual glands provided significant diagnostic utility with 100% specificity.
Global FAPI burden correlated negatively with systemic erythrocyte sedimentation rate.

Cheng et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Comparison reveals Ga-FAPI-04 PET/CT improves diagnosis of Sjögren's syndrome, suggesting higher efficacy than salivary gland scintigraphy.