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January 1, 1997Thrombosis and Haemostasis

Prolonged Thromboprophylaxis Following Hip Replacement Surgery – Results of a Double-blind, Prospective, Randomised, Placebo-controlled Study with Dalteparin (Fragmin®)

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Why the study?

Does prolonged thromboprophylaxis with dalteparin reduce the frequency of DVT in patients following hip replacement surgery?

Population

308 patients following hip replacement surgery who received initial thromboprophylaxis with dalteparin…

Comparison

Dalteparin 5000 IU once daily for 4 weeks. vs Placebo once daily for 4 weeks.

Design

RCT, randomised, double-blind, placebo-controlled

Follow-up

35 days

Authors

ODO.E. DahlOslo University HospitalGAG AndreassenOslo University HospitalTATrude AspelinOslo University Hospital

Discussion

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Implication

Extended dalteparin prophylaxis cuts late DVT after hip replacement; confirms benefit of 35-day anticoagulation in orthopedic surgery.

Structured PICO

Does prolonged thromboprophylaxis with dalteparin reduce the frequency of DVT in patients following hip replacement surgery?

P
Population
308 patients following hip replacement surgery who received initial thromboprophylaxis with dalteparin, dextran, and graded elastic stockings for 7 days, excluding those with venographically verified proximal DVT on day 7.
I
Intervention
Dalteparin 5000 IU once daily for 4 weeks (from day 7 to day 35).
C
Comparator
Placebo once daily for 4 weeks (from day 7 to day 35).
O
Outcome
Prevalence and incidence of deep venous thrombosis (DVT) on day 35, assessed by bilateral venography.hard clinical

Prolonged thromboprophylaxis with dalteparin for 35 days significantly reduces the incidence of late deep venous thrombosis following hip replacement surgery.

Cite This Study

Dahl et al. (1997) studied this question.

synapsesocial.com/papers/69fc02ad7c10856f85dd6a34https://doi.org/10.1055/s-0038-1655901
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