Lipid rafts and caveolae play a significant role in the localization and function of various cardiac ion channels, representing an important area for understanding cardiac function in health and disease.
No immediate clinical implications; leaves open whether lipid raft targeting alters arrhythmia risk or outcomes.
A variety of lipid microdomains, including caveolae, have been shown to play an important role in both protein targetting and in controlling protein-protein interactions. There is increasing evidence for significant ion channel localization in lipid rafts. Cardiac channel subunits known to localize in lipid rafts include Kv1.4, Kv1.5, Kv2.1, Kv4, Kir2, Kir3, K(ATP), Nav and Cav subunits. This article reviews what is known about the occurrence and functional significance of cardiac ion channel/lipid raft interactions. Much remains to be learned about this area of potentially enormous importance to cardiac function in health and disease.
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Maguy et al. (2006) studied this question.
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