Population
174 young patients with rheumatic aortic regurgitation
Design
Cohort
Follow-up
median 10 years
Authors
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Triad may stratify risk in rheumatic AR; leaves open optimal pre-symptomatic intervention timing pending prospective trials.
Identifies a high-risk clinical triad (LV enlargement, ECG abnormalities, abnormal blood pressure) in rheumatic aortic regurgitation that strongly predicts rapid clinical deterioration, providing criteria for timing surgical intervention before symptoms appear.
Spagnuolo et al. (1971) studied this question.
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