Effect of long-term digoxin therapy on autonomic function in patients with chronic heart failure
Why the study?
Does long-term digoxin therapy improve autonomic function in patients with mild to moderate chronic heart failure?
Population
26 patients with mild to moderate chronic heart failure
Comparison
Digoxin therapy for 4 to 8 weeks vs Baseline (before digoxin therapy)
Design
Cohort
Follow-up
4 to 8 weeks
Authors
Discussion
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Member takes
Implication
May support autonomic benefits of digoxin in mild-moderate HF; leaves open confirmation in randomized outcome trials.
Structured PICO
Does long-term digoxin therapy improve autonomic function in patients with mild to moderate chronic heart failure?
P
Population
26 patients with mild to moderate chronic heart failure
I
Intervention
Digoxin therapy for 4 to 8 weeks
C
Comparator
Baseline (before digoxin therapy)
O
Outcome
Sympathetic activity (plasma norepinephrine levels) and parasympathetic activity (heart period variability from 24-h Holter)surrogate
Long-term digoxin therapy significantly ameliorates autonomic dysfunction in patients with mild to moderate chronic heart failure by decreasing sympathetic and increasing parasympathetic activity.
Cite This Study
Krum et al. (1995) studied this question.