Why the study?
Does amiodarone therapy cause less precordial QT interval dispersion compared to class Ia antiarrhythmic drugs in patients with a history of torsade de pointes?
Population
38 consecutive patients who received both class Ia drug therapy and chronic amiodarone therapy, including 9…
Comparison
Class Ia antiarrhythmic drug therapy and chronic… vs Baseline (prior to therapy)
Design
Cohort
Authors
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Amiodarone may confer lower torsade risk than class Ia agents via unchanged QT dispersion; hypothesis-generating and requires prospective validation.
Does amiodarone therapy cause less precordial QT interval dispersion compared to class Ia antiarrhythmic drugs in patients with a history of torsade de pointes?
Class Ia antiarrhythmic drugs increase regional QT interval dispersion, which is associated with torsade de pointes, whereas amiodarone produces comparable QT prolongation without increasing dispersion, explaining its relative safety.
Hii et al. (1992) studied this question.
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