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June 1, 1990HeartOpen Access

QT dispersion: an indication of arrhythmia risk in patients with long QT intervals.

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Why the study?

Does QTc dispersion indicate arrhythmia risk in patients with long QT intervals?

Population

24 patients with prolonged QT intervals, including 10 with an arrhythmogenic long QT interval and 14 without…

Comparison

Measurement of QTc dispersion vs Patients without arrhythmias with…

Design

Case-control

Authors

CDChristopher P. DayUniversity Hospitals of North Midlands NHS TrustJMJanet M. McCombNewcastle upon Tyne Hospitals NHS Foundation TrustRCR. W. F. CampbellAllegheny Health Network

Discussion

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Implication

QTc dispersion may aid arrhythmia risk stratification in prolonged QT; observational data leave open prospective validation before clinical use.

Key Points

  • The aim is to evaluate QT dispersion as a predictor of arrhythmia risk in patients with prolonged QT intervals.
  • Compared QT dispersion in patients with arrhythmogenic long QT syndrome and sotalol-induced QT prolongation.
  • Included 10 patients with arrhythmias and 14 without.
  • Measured maximum and minimum QT intervals to calculate QTc dispersion.
  • QTc dispersion was significantly greater in the arrhythmogenic group than in the sotalol group (exact p-value not stated).
  • QT dispersion effectively differentiated between patients experiencing ventricular arrhythmias and those without.
  • Findings support the role of QT dispersion as a reflection of myocardial recovery time.

Structured PICO

Does QTc dispersion indicate arrhythmia risk in patients with long QT intervals?

P
Population
24 patients with prolonged QT intervals, including 10 with an arrhythmogenic long QT interval (Romano Ward and Jervell and Lange-Nielsen syndromes or drug arrhythmogenicity) and 14 without arrhythmias in whom the QT interval was prolonged by sotalol.
I
Intervention
Measurement of QTc dispersion (difference between the maximum and minimum body surface QT interval)
C
Comparator
Patients without arrhythmias with sotalol-prolonged QT intervals
O
Outcome
QTc dispersionsurrogate

QTc dispersion can distinguish between arrhythmogenic and non-arrhythmogenic prolonged QT intervals, serving as a potential non-invasive marker for arrhythmia risk.

Cite This Study

Day et al. (1990) studied this question.

synapsesocial.com/papers/69fc052d3a0f4cc134c8eeb7https://doi.org/10.1136/hrt.63.6.342
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of bretylium tosylate on inhomogeneity of refractoriness and ventricular fibrillation threshold in canine hearts with quinidine-induced long QT interval1985 · 14 citations
  2. 2Confidence intervals rather than P values: estimation rather than hypothesis testing.1986 · 2,047 citations
  3. 3Hereditary prolongation of QT interval.1972 · 35 citations
  4. 4De subitaneis mortibus. XXX. Observations on the pathophysiology of the long QT syndromes with special reference to the neuropathology of the heart.1978 · 109 citations