March 24, 2003Circulation
Why Are Patients With Chronic Obstructive Pulmonary Disease at Increased Risk of Cardiovascular Diseases?
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Overview
Cross-sectional study reveals systemic inflammation associates with cardiac injury in chronic obstructive pulmonary disease, suggesting an inflammatory link to cardiovascular risk.
Key Points
- To determine whether circulating systemic inflammatory markers are elevated in individuals with chronic airflow obstruction and whether they correlate with an increased risk of cardiac injury.
- Analyzed cross-sectional data from 6,629 participants aged 50 years or older from the Third National Health and Nutrition Examination Survey (NHANES III).
- Measured circulating inflammatory markers, including C-reactive protein, leukocytes, platelets, and fibrinogen, alongside electrocardiographic evidence of ischemia and Cardiac Infarction Injury Scores.
- Severe airflow obstruction was associated with significantly higher circulating leukocytes (+460/microL; 95% CI, 30 to 890), platelets (+39,510/microL; 95% CI, 21,730 to 57,290), fibrinogen (+41.63 mg/dL; 95% CI, 19.87 to 63.39), and an elevated C-reactive protein level (OR 2.18; 95% CI, 1.46 to 3.27).
- Participants with both elevated C-reactive protein and moderate or severe airflow obstruction had Cardiac Infarction Injury Scores that were 2.68 U and 5.88 U higher, respectively, than those without obstruction and with low C-reactive protein.
Cite This Study
Sin et al. (2003) studied this question.