P2Y12 inhibitor monotherapy or dual antiplatelet therapy after coronary revascularisation: individual patient level meta-analysis of randomised controlled trials

Figures

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  Fig 1. Hazard ratios for individual trials and for pooled population and Kaplan-Meier estimates for primary endpoint of all cause death, myocardial infarction, or stroke in intention to treat population. Kaplan-Meier curves and hazard ratios from one step, fixed effect meta-analysis (top) and two step, fixed effect meta-analysis (bottom). DAPT=dual antiplatelet therapy; P2Y12i=P2Y12 inhibitor monotherapy

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  Fig 2. Subgroup analyses for primary endpoint of all cause death, myocardial infarction, or stroke in intention to treat population. High bleeding risk was defined on basis of PRECISE-DAPT score ≥25. *P value obtained by merging within study and across study interactions (owing to design of trials). †European regions pooled together and within study and across study interactions merged owing to trial designs. ACS=acute coronary syndrome; CABG=coronary artery bypass grafting; CAD=coronary artery disease; CKD=chronic kidney disease; DAPT=dual antiplatelet therapy; LAD=left anterior descending artery; P2Y12i=P2Y12 inhibitor monotherapy; PCI=percutaneous coronary intervention

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  Fig 3. Sex stratified analysis for primary endpoint, all cause death, cardiovascular death, myocardial infarction, or stroke in intention to treat population. DAPT=dual antiplatelet therapy; P2Y12i=P2Y12 inhibitor monotherapy

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  Fig 4. Primary endpoint or its components and key safety endpoint stratified by use of clopidogrel or newer P2Y12 inhibitors in experimental arm of intention to treat population. BARC=Bleeding Academy Research Consortium; DAPT=dual antiplatelet therapy

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  Fig 5. Hazard ratios for individual trials and for pooled population and Kaplan-Meier estimates for key safety endpoint of Bleeding Academic Research Consortium (BARC) type 3 or type 5 bleeding in intention to treat population. Kaplan-Meier curves and hazard ratios from one step, fixed effect meta-analysis (top) and two step, fixed effect meta-analysis (bottom). DAPT=dual antiplatelet therapy