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To enhance the prompt administration of the first antibiotic dose for suspected neonatal sepsis in the NICU.

Timely administration of antibiotics for neonatal sepsis in the neonatal intensive care unit: A quality improvement initiative

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To enhance the prompt administration of the first antibiotic dose for suspected neonatal sepsis in the NICU.
Conducted in a 53-bed NICU over 3 years involving 1094 neonates with suspected sepsis.
Implemented staff education, developed order sets for stat doses, and launched a secure medication delivery system.
Measured outcomes included administration time within 60 minutes and average time from order to administration.
Infants receiving antibiotics within 60 minutes improved from 32.7% to 84.4% over 3 years.
Average time to antibiotic administration decreased from 93.3 minutes to 44.7 minutes.
The improvements were sustained over a 2-year period.

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Randomized trial improves timely antibiotic delivery in neonates, suggesting effective interventions.

Singh et al. (2026) studied this question.

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