Parkinson's Disease This cover depicts copper-induced disruption of proteostasis in a Parkinson's disease cellular model. Copper overload impairs autophagic flux and ubiquitin–proteasome system activity, promoting neuritic accumulation of phosphorylated α-synuclein. The image emphasizes metal dyshomeostasis as a driving factor in α-synuclein pathology and neurodegenerative mechanisms. More details can be found in the Research Article by Debora Musarò, Michele Maffia, and co-workers (DOI: 10.1002/adbi.202500274).
Musarò et al. (Fri,) studied this question.