Stress Markers and Post-COVID Insomnia: Investigating Copeptin and Melatonin Levels in Post-COVID-19

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Key Points

The study aims to investigate the roles of copeptin and melatonin in insomnia among COVID-19 recovered individuals.
Included 30 COVID-19-recovered patients and 15 healthy controls, categorized by insomnia severity index (ISI) scores.
Insomnia patients received either trazodone 50 mg or mirtazapine 15 mg daily for three months.
Serum levels of copeptin and melatonin were measured and compared between groups.
Statistically significant differences in melatonin and copeptin levels between insomnia and non-insomnia groups (p<0.05).
Insomnia patients treated with trazodone or mirtazapine showed improvements in sleep metrics over three months.

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Investigates insomnia treatment effects on copeptin and melatonin in COVID-19 survivors, suggesting important biomarkers for better sleep management.

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Güzelgül et al. (2026) studied this question.

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