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May 7, 2026

Testosterone-to-Follicle Stimulating Hormone Ratio Predicts Sperm Retrieval Success in Men with Idiopathic Non-Obstructive Azoospermia.

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Authors

JSJayant SivaBNBryan NaelitzSVSanjay Vallabhaneni

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Overview

Randomized trial evaluates hormonal predictors of sperm retrieval success in men with azoospermia, indicating a reliable metric for clinical predictions.

Key Points

  • To identify preoperative hormonal predictors for successful sperm retrieval in men with idiopathic non-obstructive azoospermia.
  • Retrospective cohort study with 60 men undergoing microsurgical testicular sperm extraction.
  • Measured serum levels of testosterone, follicle-stimulating hormone, and luteinizing hormone.
  • Used logistic regression and area under the curve to evaluate predictive performance.
  • Higher T/FSH ratio in successful sperm retrieval cases (43.0 vs. 20.9, p=0.004).
  • T/FSH ratio showed an AUC of 0.81 for predicting outcomes.
  • The two-step predictive model achieved 93% sensitivity and 81% specificity for sperm retrieval success.

Cite This Study

Siva et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c718b49bacb8b347f69https://doi.org/10.1016/j.fertnstert.2026.04.023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management of non‐obstructive azoospermia2016 · 131 citations
  2. 2Predictors of Successful Testicular Sperm Extraction: A New Era for Men with Non-Obstructive Azoospermia2024 · 17 citations
  3. 3Testosterone to Luteinizing Hormone Ratio as a Potential Predictor of Sperm Retrieval in Non-Obstructive Azoospermia Patients2023 · 17 citations
  4. 4Predictive factors of successful salvage microdissection testicular sperm extraction (mTESE) after failed mTESE in patients with non-obstructive azoospermia: Long-term experience at a single institute2018 · 24 citations
  5. 5Predictors of testicular sperm retrieval in patients with non-obstructive azoospermia: a review2021 · 36 citations