Synthesis, characterization, and α-glucosidase inhibitory activity of methyl proline derivatives of phenylpropanoid

Key Points

• This research aims to synthesize and evaluate the α-glucosidase inhibitory effects of methyl proline derivatives of phenylpropanoid.
• Synthesized six proline-phenylpropanoid derivatives including 6f.
• Conducted molecular docking to analyze binding interactions and stability.
• Performed DFT/ADME analyses to assess compound properties.
• 6f exhibited potent α-glucosidase inhibition with an IC 50 of 91 µM.
• Molecular docking demonstrated stable binding via π–π stacking and hydrogen bonds.
• DFT/ADME analyses supported the compound's suitability for further development.