What question did this study set out to answer?

To determine how well retinal ganglion cells can follow repetitive indirect electrical stimulation mediated through the retinal neural network.

January 24, 2007Journal of Neural Engineering

Responses of ganglion cells to repetitive electrical stimulation of the retina

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Authors

RJRalph J. JensenVA Boston Healthcare System JRJoseph F. RizzoMassachusetts Eye and Ear Infirmary

Discussion

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Overview

Ex vivo experimental study demonstrates frequency-dependent response depression in rabbit retinal ganglion cells, highlighting constraints for retinal prosthesis design.

Key Points

To determine how well retinal ganglion cells can follow repetitive indirect electrical stimulation mediated through the retinal neural network.
Recorded spike activity of retinal ganglion cells in isolated rabbit retina.
Delivered paired electrical pulses across varying interpulse intervals (down to 15 ms) and pulse trains of 10 pulses at multiple stimulation frequencies.
Response amplitude diminished when a stimulus pulse was applied within 400 ms of a preceding pulse, with depression worsening at shorter intervals.
At the shortest interpulse interval of 15 ms, the response amplitude to the second pulse decreased by an average of 94%.
Ten-pulse stimulus trains produced further response depression at high stimulation frequencies, though the decrease across successive pulses was moderate relative to the initial drop after the first pulse.

Cite This Study

Jensen et al. (2007) studied this question.

synapsesocial.com/papers/69fc4651fb087793c078d6c3 https://doi.org/10.1088/1741-2560/4/1/s01

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January 24, 2007Journal of Neural Engineering

Responses of ganglion cells to repetitive electrical stimulation of the retina

View Full Paper

Ask AI

Bookmark

Authors

RJRalph J. JensenVA Boston Healthcare System JRJoseph F. RizzoMassachusetts Eye and Ear Infirmary

Discussion

Member takes

Overview

Ex vivo experimental study demonstrates frequency-dependent response depression in rabbit retinal ganglion cells, highlighting constraints for retinal prosthesis design.

Key Points

To determine how well retinal ganglion cells can follow repetitive indirect electrical stimulation mediated through the retinal neural network.
Recorded spike activity of retinal ganglion cells in isolated rabbit retina.
Delivered paired electrical pulses across varying interpulse intervals (down to 15 ms) and pulse trains of 10 pulses at multiple stimulation frequencies.
Response amplitude diminished when a stimulus pulse was applied within 400 ms of a preceding pulse, with depression worsening at shorter intervals.
At the shortest interpulse interval of 15 ms, the response amplitude to the second pulse decreased by an average of 94%.
Ten-pulse stimulus trains produced further response depression at high stimulation frequencies, though the decrease across successive pulses was moderate relative to the initial drop after the first pulse.

Cite This Study

Jensen et al. (2007) studied this question.

synapsesocial.com/papers/69fc4651fb087793c078d6c3 https://doi.org/10.1088/1741-2560/4/1/s01

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