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November 18, 2005ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)

DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

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Population

A subject diagnosed with schizophrenia and a relative with chronic psychiatric illness, and cellular models

Comparison

Elevation of cellular cAMP vs Resting cells

Design

Preclinical

Authors

JMJ. Kirsty MillarInstitute of Genetics and CancerBPBen PickardTulane UniversitySMShaun MackieInstitute of Genetics and Cancer

Discussion

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Implication

Hypothesis-generating for DISC1-PDE4B in schizophrenia; human validation required before any clinical consideration.

Structured PICO

P
Population
A subject diagnosed with schizophrenia and a relative with chronic psychiatric illness, and cellular models
I
Intervention
Elevation of cellular cAMP
C
Comparator
Resting cells
O
Outcome
Dissociation of PDE4B from DISC1 and increase in PDE4B activitysurrogate

DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP, providing a mechanistic model for its role in schizophrenia.

Cite This Study

Millar et al. (2005) studied this question.

synapsesocial.com/papers/69fc7fdb2bd1d6a2a7dda89ehttps://doi.org/10.1126/science.1112915
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Schizophrenia and Affective Disorders—Cosegregation with a Translocation at Chromosome 1q42 That Directly Disrupts Brain-Expressed Genes: Clinical and P300 Findings in a Family2001 · 742 citations
  2. 2Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 12005 · 75 citations