Why the study?
Coronary computed tomography mapping of pericoronary adipose tissue radiodensity quantifies coronary inflammation, but significant knowledge gaps in performance and measurement complicate its interpretation.
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Design
Review
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This review summarizes the role of pericoronary adipose tissue (PCAT) radiodensity on coronary CT as a novel noninvasive biomarker of coronary inflammation and cardiovascular risk.
Vascular inflammation is a key driver in atherosclerotic progression and plaque rupture. Recent evidence has shown that coronary computed tomography provides a noninvasive method of quantifying coronary inflammation by mapping changes in pericoronary adipose tissue (PCAT) radiodensity, which are associated with cardiovascular diseases. However, there are significant knowledge gaps in the performance and measurement of PCAT that complicate its interpretation. In this review the authors aim to summarize the role of PCAT in cardiac imaging and explore the clinical implications and applicability as a novel biomarker of cardiovascular risk, as well as to discuss its limitations and potential pitfalls.
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Tan et al. (2023) studied this question.
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