Myosin Heavy Chain Isoform Expression in the Failing and Nonfailing Human Heart
Population
22 human heart samples (12 nonfailing hearts and 10 end-stage failing left ventricles)
Design
Other
Authors
Discussion
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Member takes
Implication
May indicate molecular basis for contractile impairment in end-stage HF; leaves open whether restoring alphaMyHC could be therapeutic.
Structured PICO
P
Population
22 human heart samples (12 nonfailing hearts and 10 end-stage failing left ventricles)
O
Outcome
MyHC protein isoform content (specifically alphaMyHC protein levels)surrogate
The alphaMyHC protein is detectable in nonfailing human hearts but becomes effectively undetectable in end-stage heart failure, suggesting a molecular basis for diminished cardiac contractility.
Cite This Study
Miyata et al. (2000) studied this question.