What question did this study set out to answer?

To characterize female C57BL/6J mice maintained on a high-fat diet as an experimental model for impaired glucose tolerance and early type 2 diabetes, and to test their responsiveness to pharmacological intervention.

December 1, 2004DiabetesOpen Access

The High-Fat Diet–Fed Mouse

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Authors

MWMaria Sörhede WinzellAstraZeneca (Sweden)BÅBo ÅhrénLinköping University

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Implication

Preclinical study reveals rapid glucose intolerance and progressive hyperinsulinemia in high-fat diet–fed mice, indicating a robust model for testing type 2 diabetes therapies.

Key Points

To characterize female C57BL/6J mice maintained on a high-fat diet as an experimental model for impaired glucose tolerance and early type 2 diabetes, and to test their responsiveness to pharmacological intervention.
Female C57BL/6J mice were fed either a high-fat diet (58% energy from fat) or a normal control diet (11% fat) over a 12-month study period.
Circulating glucose, insulin levels, and metabolic responses were evaluated using intravenous and oral glucose tolerance tests.
Mice were treated with an oral dipeptidyl peptidase-IV inhibitor (LAF237 at 0.3 mg/ml in drinking water) for 4 weeks to evaluate therapeutic reversal of glucose intolerance.
High-fat diet feeding caused higher body weight and raised circulating glucose by approximately 1 mmol/l within 1 week, maintaining this elevation across the 12-month evaluation.
Mice developed severe glucose intolerance and a compromised insulin response to intravenous glucose challenge after 1 week, alongside a progressive rise in baseline circulating insulin over time.
Treatment with LAF237 for 4 weeks normalized glucose tolerance during an oral glucose tolerance test and augmented insulin secretion.

Cite This Study

Winzell et al. (2004) studied this question.

synapsesocial.com/papers/69fcc6513d23f8b451dda6e3 https://doi.org/10.2337/diabetes.53.suppl_3.s215

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Implication

Preclinical study reveals rapid glucose intolerance and progressive hyperinsulinemia in high-fat diet–fed mice, indicating a robust model for testing type 2 diabetes therapies.

The High-Fat Diet–Fed Mouse

Discussion

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Implication

Key Points

Cite This Study

The High-Fat Diet–Fed Mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

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