The palladium-catalyzed reaction between o-alkynyltrifluoroacetanilides and aryl and vinyl iodides, bromides or triflates, alkyl halides and allyl esters has been developed into an efficient and versatile procedure for the construction of substituted pyrrole nuclei incorporated into indole systems. The reaction can be performed in the presence of carbon monoxide, producing indoles incorporating a molecule of carbon monoxide. In this Microreview, we discuss the concept of this useful approach to the preparation of a variety of indole derivatives and comment on the parameters influencing the reaction outcome. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
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Battistuzzi et al. (2002) studied this question.