What question did this study set out to answer?

Investigate whether endocrine secretory granules utilize amyloid-like protein conformations to naturally store peptide and protein hormones.

June 18, 2009ScienceOpen Access

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

View Full Paper

Ask AI

Bookmark

Authors

SMSamir K. MajiIndian Institute of Technology Bombay MPMarilyn H. PerrinSalk Institute for Biological Studies MSM.R. SawayaEötvös Loránd University

Discussion

Member takes

Implication

Biochemical analysis reveals peptide hormones store as functional amyloids in endocrine secretory granules, indicating amyloid structures support normal physiology.

Key Points

Investigate whether endocrine secretory granules utilize amyloid-like protein conformations to naturally store peptide and protein hormones.
Analyzed the structural conformation of peptide and protein hormones housed inside endocrine secretory granules.
Evaluated hormonal aggregate architecture for characteristic cross-beta-sheet-rich signatures in pituitary tissue.
Endocrine peptide and protein hormones naturally condense into an organized, cross-beta-sheet-rich amyloid-like state within secretory granules.
Functional amyloid assembly operates as a physiological storage mechanism in the pituitary and endocrine tissues without eliciting cellular pathology.

Cite This Study

Maji et al. (2009) studied this question.

synapsesocial.com/papers/69fcebe7015782f43c509193 https://doi.org/10.1126/science.1173155

View Full Paper

Ask AI

Bookmark

Implication

Biochemical analysis reveals peptide hormones store as functional amyloids in endocrine secretory granules, indicating amyloid structures support normal physiology.

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Discussion

Member takes

Implication

Key Points

Cite This Study

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider