Why the study?
Does bisoprolol reduce mortality in patients with chronic heart failure and LVEF < 40%?
Population
641 patients with chronic heart failure of various etiologies, LVEF < 40%, and NYHA functional class III or…
Comparison
Bisoprolol added to background diuretic and… vs Placebo added to background diuretic and…
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
mean 1.9 years
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No significant mortality reduction with bisoprolol in chronic HF and LVEF <40%; leaves open effects on hospitalizations.
Does bisoprolol reduce mortality in patients with chronic heart failure and LVEF < 40%?
In patients with severe chronic heart failure, bisoprolol did not significantly improve survival but did significantly reduce hospitalizations for cardiac decompensation and improved functional status.
A 1994 study studied this question.