Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents.
Population
Single myocytes isolated from right atrial specimens obtained from patients undergoing coronary bypass surgery
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Positions Isus as regulator of human atrial repolarization; leaves open Kv1.5 inhibition as antiarrhythmic strategy.
Structured PICO
P
Population
Single myocytes isolated from right atrial specimens obtained from patients undergoing coronary bypass surgery
I
Intervention
Whole-cell voltage-clamp techniques and pharmacological agents (e.g., 4-aminopyridine)
O
Outcome
Electrophysiological properties and ionic mechanism of the sustained outward current (Isus)surrogate
Identifies a novel, rapidly activating delayed rectifier K+ current (Isus) in human atrial myocytes that resembles Kv1.5 channels and regulates action potential duration.
Cite This Study
Wang et al. (1993) studied this question.