This report provides a pathological comparison of a novel type of spontaneous coronary atherosclerosis characterized by triglyceride deposition against typical cholesterol-driven atherosclerosis.
Does not alter lipid management; leaves open whether triglyceride-dominant lesions represent a distinct, targetable atherosclerosis subtype.
Unlike cholesterol, roles of triglyceride (TG) in the atherogenesis are largely unknown. We previously reported a 41-year-old male with a genetic deficiency of adipose triglyceride lipase (ATGL) exhibiting profound TG accumulation in coronary arteries. Here, we pathologically compare his unusual TG-deposit coronary atherosclerosis with usual cholesterol-deposit atherosclerosis in a patient with ischaemic cardiomyopathy. Both patients received cardiac …
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Ikeda et al. (2013) studied this question.
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