Why the study?
Elevated LA pressure in HFpEF leads to LA enlargement, which may impair LA function and raise pulmonary pressures, prompting evaluation of the relationship between LA volume and pulmonary arterial haemodynamics.
Is left atrial enlargement associated with pulmonary vascular disease in patients with heart failure with preserved ejection fraction?
Is left atrial enlargement associated with pulmonary vascular disease in patients with heart failure with preserved ejection fraction?
In patients with HFpEF, increasing left atrial volume and reduced left atrial function are associated with more advanced pulmonary vascular disease and impaired pulmonary haemodynamics.
Reduced LA strain may signal advanced pulmonary vascular disease in HFpEF; leaves open causal and prognostic implications.
AIMS: Elevated left atrial (LA) pressure is a pathophysiologic hallmark of heart failure with preserved ejection fraction (HFpEF). Chronically elevated LA pressure leads to LA enlargement, which may impair LA function and increase pulmonary pressures. We sought to evaluate the relationship between LA volume and pulmonary arterial haemodynamics in patients with HFpEF. METHODS AND RESULTS: <0.001), with reduced strain associated with reduced PVR-compliance time (0.34 [0.28-0.40] vs. 0.38 [0.33-0.43], p = 0.03). CONCLUSION: Increasing LA volume may be associated with more advanced pulmonary vascular disease in HFpEF, featuring higher PVR and pulmonary pressures. Reduced LA function, worse at increasing LA volumes, is associated with a disrupted PVR-compliance relationship, further augmenting impaired pulmonary haemodynamics.
No takes yet. Share an insight, caveat, or question.
Gard et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: