Sensitive Troponin I Assay in Early Diagnosis of Acute Myocardial Infarction
Why the study?
Does a sensitive troponin I assay improve the early diagnosis and risk stratification of acute myocardial infarction in patients with suspected AMI compared to troponin T and traditional markers?
Population
1818 consecutive patients with suspected acute myocardial infarction
Comparison
Sensitive troponin I assay measured on… vs Troponin T assay and traditional myocardial…
Design
Cohort
Follow-up
30 days
Authors
Discussion
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Member takes
Implication
May support sensitive troponin I for early AMI diagnosis; leaves open superiority over troponin T in prospective trials.
Structured PICO
Does a sensitive troponin I assay improve the early diagnosis and risk stratification of acute myocardial infarction in patients with suspected AMI compared to troponin T and traditional markers?
P
Population
1818 consecutive patients with suspected acute myocardial infarction
I
Intervention
Sensitive troponin I assay (cutoff value, 0.04 ng/mL) measured on admission, and at 3 and 6 hours after admission
C
Comparator
Troponin T assay and traditional myocardial necrosis markers
O
Outcome
Diagnostic accuracy (Area Under the Curve [AUC]) for early diagnosis of acute myocardial infarctionsurrogate
A sensitive troponin I assay provides superior diagnostic accuracy for early acute myocardial infarction compared to standard troponin T and independently predicts 30-day adverse outcomes.
Cite This Study
Keller et al. (2009) studied this question.