Why the study?
The failing heart undergoes profound metabolic reprogramming through altered cardiac gene expression, but the role of cardiac DNA methylation in encoding these metabolic changes was unknown.
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Population
Patients with end-stage human heart failure
DNA methylation may drive metabolic reprogramming in HF; leaves open epigenetic targets for restoring oxidative metabolism.
The failing heart undergoes profound metabolic changes because of alterations in cardiac gene expression, reactivating glycolytic genes and suppressing oxidative metabolic genes. In the current study, we discover that alterations to cardiac DNA methylation encode this fetal-like metabolic gene reprogramming. We also identify novel epigenetic interference of nuclear respiratory factor 1 via hypermethylation of its downstream promoter targets, further supporting a novel contribution of DNA methylation in the metabolic remodeling of heart failure.
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Pepin et al. (2019) studied this question.
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