Paroxysmal AF carries a high risk of embolic stroke in HCM patients, supporting the early introduction of anticoagulation therapy at first documentation.
Paroxysmal AF was associated with embolic stroke in HCM; hypothesis-generating for early anticoagulation, requires prospective confirmation.
One-third of HCM patients with AF developed embolic stroke, and male HCM patients were younger at the time of the embolic stroke than female HCM patients. The prevalence of paroxysmal AF was significantly higher than that of chronic AF in patients with AF and embolic stroke. Early introduction of anticoagulation therapy is recommended at the first documentation of paroxysmal AF.
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Komatsu et al. (2021) studied this question.
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